Stellar Stem Cells

Establishing In-Space Production of Stem Cell Therapies
Stellar Stem Cells

This project seeks insights into the impact of microgravity on producing stem cells and stem cell-derived products in space.  Using space to evaluate the steps used in terrestrial manufacturing to reprogram skin cells (fibroblasts) into stem cells capable of producing a variety of tissue types (heart, brain, and blood), could support regenerative medicine uses on Earth. Axiom Space is contributing to the NASA-funded In-Space Production Applications project through the Ax-2 mission.

PUBLICATION
Surface tension enables induced pluripotent stem cell culture in commercially available hardware during spaceflight
  • First successful iPSC culture using commercial hardware in space
  • Surface tension enables fluid handling in microgravity
  • First demonstration of DNA transfection in space-grown stem cells
  • Spontaneous 3D spheroid formation in microgravity
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